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Growth factor molecules containing the cystine-knot motif serve as ligands for a diverse range of receptors and play an important role in extracellular ...
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Cystine-Knot Group of Growth Factors. Cystine-knot proteins are small proteins composed of approximately 30 amino acid residues, with a characteristic tertiary ...
Aug 3, 2017 · Many growth factor cystine knot proteins are stabilised by intermolecular disulfide bonds. In contrast, proteins belonging to the knottin group ...
Abstract. Four recent crystal structures of growth factors--nerve growth factor, transforming growth factor-beta, platelet-derived growth factor, and human ...
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The largest 10-membered cystine knot subfamily is the TGFβ family that consists of transforming growth factors, bone morphogenetic proteins (BMP), growth ...
complex demonstrates how a trimeric ligand is able to induce receptor trimerization, which may then trigger sig- nal transduction and activation (Banner et ...
Aug 30, 2002 · The Cystine Knot Promotes Folding and Not Thermodynamic Stability in Vascular Endothelial Growth Factor* ... Cystine knots consist of three ...
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling ...
Aug 31, 2009 · Nevertheless, cystine knot proteins belong to two large superfamilies named knottins [3, 4] and cystine-knot Growth Factor related proteins [5].
Sep 30, 2021 · The hypothesis was that a partially unfolded cystine knot, in which one or two cysteines were eliminated by partial reduction and alkylation, ...